What does a reaction query tell you?

• Whether a planned transformation has precedent
• The price of the reagents
• The journal impact factor

What does a substructure query find?

• Compounds containing your drawing, whatever they were called
• Only papers with your exact title words
• Only compounds your group made

A review article counts as the primary procedure for a reaction.

Circle one:   True   False

How do you turn a planned coupling into a good reaction query?

• Copy the whole target molecule exactly
• Draw the bond change with the right level of generality
• Search the author names first

Your substructure search returns thousands of hits. What is the sensible move?

• Read all of them in order
• Abandon the search entirely
• Narrow toward your ring and substituents

A review cites the reaction you need. What do you do next?

• Trace the citation to the first paper and read its conditions
• Cite the review and start the reaction
• Email the review author for permission

Your careful search returns nothing. What does that mean for the plan?

• The step is proven impossible
• There is no precedent, so the step is untested risk
• The databases are broken

A hit shares your substrate name but reacts at different atoms. How do you judge it?

• Real precedent, names match
• Real precedent, journals rarely err
• Superficial, the reacting atoms differ