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Pathogens & the Immune System

Explain how pathogens (bacteria, viruses, and fungi) cause disease and describe how the immune system responds, including the roles of white blood cells (phagocytosis, antibody production) and the concept of immunity

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What a learner can do afterwards

  • Distinguishes between bacteria, viruses, and fungi as pathogens with examples of each
  • Explains two ways white blood cells destroy pathogens (engulfing and antibodies)
  • Explains how vaccination works and why it prevents disease
  • Explains the difference between being infected and being ill

The lesson

A pathogen is a germ that causes disease. There are three main kinds: bacteria, viruses, and fungi. Strep throat comes from bacteria. The flu comes from a virus. Athlete's foot comes from a fungus. All three make you feel sick, but they are different types of germs, and that is why the same medicine does not work on all of them.

Virus100Bacteria2000Fungus5000
Pathogens are not all the same size. Viruses are the smallest by far, bacteria are much bigger, and fungi are bigger still.

Your body fights pathogens with white blood cells. Some white blood cells engulf a pathogen, swallowing it whole and breaking it down. Other white blood cells make antibodies, small proteins shaped to lock onto one specific pathogen and mark it so it can be destroyed.

Good to know

A vaccine is a safe, weakened or dead piece of a pathogen. It cannot make you sick, but it lets your white blood cells practice making antibodies for that exact pathogen ahead of time, so your body is ready if the real one ever shows up.

Try it together

Mia picks up a cold virus at school on Monday. For two days her immune system fights it before she has any symptoms, so she is infected but not ill yet. On Wednesday her nose starts running and she coughs. Now she is infected and ill.

Bacteria, viruses, and fungi are different pathogens, white blood cells fight them by engulfing them or making antibodies, and a vaccine trains that defense before you ever get sick.

Watch it

Where it sits

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Then practise

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Pathogens & the Immune System · Science, ages 12 to 14 · LightMySky